[Taste receptors in the lungs: interesting or anecdotal?].
Identifieur interne : 000175 ( France/Analysis ); précédent : 000174; suivant : 000176[Taste receptors in the lungs: interesting or anecdotal?].
Auteurs : S. Grassin-Delyle [France] ; C. Abrial [France] ; M. Brollo [France] ; E. Naline [France] ; P. Devillier [France]Source :
- Revue de pneumologie clinique [ 1776-2561 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cellules épithéliales (physiologie), Cils vibratiles (physiologie), Goût (physiologie), Humains, Myocytes du muscle lisse (physiologie), Poumon (), Poumon (cytologie), Poumon (physiologie), Relâchement musculaire (physiologie), Récepteurs couplés aux protéines G (agonistes), Récepteurs couplés aux protéines G (physiologie), Récepteurs de surface cellulaire (physiologie).
- MESH :
- agonistes : Récepteurs couplés aux protéines G.
- cytologie : Poumon.
- physiologie : Cellules épithéliales, Cils vibratiles, Goût, Myocytes du muscle lisse, Poumon, Relâchement musculaire, Récepteurs couplés aux protéines G, Récepteurs de surface cellulaire.
- Animaux, Humains, Poumon.
English descriptors
- KwdEn :
- Animals, Cilia (physiology), Epithelial Cells (physiology), Humans, Lung (chemistry), Lung (cytology), Lung (physiology), Muscle Relaxation (physiology), Myocytes, Smooth Muscle (physiology), Receptors, Cell Surface (physiology), Receptors, G-Protein-Coupled (agonists), Receptors, G-Protein-Coupled (physiology), Taste (physiology).
- MESH :
- chemical , agonists : Receptors, G-Protein-Coupled.
- chemical , physiology : Receptors, Cell Surface, Receptors, G-Protein-Coupled.
- chemistry : Lung.
- cytology : Lung.
- physiology : Cilia, Epithelial Cells, Lung, Muscle Relaxation, Myocytes, Smooth Muscle, Taste.
- Animals, Humans.
Abstract
The receptors responsible for taste perception distinguish the four basic tastes : salty, sweet, bitter and umami. Among them, the bitter taste receptors (TAS2R) are G protein coupled receptors, including 25 subtypes identified in humans to date. Although the existence of endogenous agonists remains uncertain, the TAS2R receptors have the ability to recognize natural or synthetic molecules, as various molecules produced by bacteria, or caffeine, chloroquine, or erythromycin. The expression of these receptors, initially thought to be confined to the oral cavity, has recently been described in extra-oral tissues such as the gastrointestinal tract and the lungs. The effects in the lung tissue are essentially at three levels : TAS2R receptors expressed on the cilia of epithelial cells increase the cilia vibration frequency; the stimulation of TAS2R receptors expressed in bronchial smooth muscle cells leads to bronchial relaxation; while TAS2R receptors expressed on immune cells in the lung tissue, including macrophages, are involved in the modulation of the production of pro-inflammatory cytokines. In conclusion, in view of these complementary mechanisms, TAS2R receptors may become a pharmacological target of interest for the treatment of obstructive lung diseases.
DOI: 10.1016/j.pneumo.2013.11.008
PubMed: 24646786
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000299
- to stream PubMed, to step Curation: 000299
- to stream PubMed, to step Checkpoint: 000268
- to stream Ncbi, to step Merge: 000243
- to stream Ncbi, to step Curation: 000243
- to stream Ncbi, to step Checkpoint: 000243
- to stream Main, to step Merge: 001003
- to stream Main, to step Curation: 001002
- to stream Main, to step Exploration: 001002
- to stream France, to step Extraction: 000175
Links to Exploration step
pubmed:24646786Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Taste receptors in the lungs: interesting or anecdotal?].</title><author><name sortKey="Grassin Delyle, S" sort="Grassin Delyle, S" uniqKey="Grassin Delyle S" first="S" last="Grassin-Delyle">S. Grassin-Delyle</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France. Electronic address: s.grassindelyle@hopital-foch.org.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author><author><name sortKey="Abrial, C" sort="Abrial, C" uniqKey="Abrial C" first="C" last="Abrial">C. Abrial</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author><author><name sortKey="Brollo, M" sort="Brollo, M" uniqKey="Brollo M" first="M" last="Brollo">M. Brollo</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author><author><name sortKey="Naline, E" sort="Naline, E" uniqKey="Naline E" first="E" last="Naline">E. Naline</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Montigny-Le-Bretonneux</settlement></placeName></affiliation></author><author><name sortKey="Devillier, P" sort="Devillier, P" uniqKey="Devillier P" first="P" last="Devillier">P. Devillier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Montigny-Le-Bretonneux</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24646786</idno><idno type="pmid">24646786</idno><idno type="doi">10.1016/j.pneumo.2013.11.008</idno><idno type="wicri:Area/PubMed/Corpus">000299</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000299</idno><idno type="wicri:Area/PubMed/Curation">000299</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000299</idno><idno type="wicri:Area/PubMed/Checkpoint">000268</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000268</idno><idno type="wicri:Area/Ncbi/Merge">000243</idno><idno type="wicri:Area/Ncbi/Curation">000243</idno><idno type="wicri:Area/Ncbi/Checkpoint">000243</idno><idno type="wicri:Area/Main/Merge">001003</idno><idno type="wicri:Area/Main/Curation">001002</idno><idno type="wicri:Area/Main/Exploration">001002</idno><idno type="wicri:Area/France/Extraction">000175</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Taste receptors in the lungs: interesting or anecdotal?].</title><author><name sortKey="Grassin Delyle, S" sort="Grassin Delyle, S" uniqKey="Grassin Delyle S" first="S" last="Grassin-Delyle">S. Grassin-Delyle</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France. Electronic address: s.grassindelyle@hopital-foch.org.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author><author><name sortKey="Abrial, C" sort="Abrial, C" uniqKey="Abrial C" first="C" last="Abrial">C. Abrial</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author><author><name sortKey="Brollo, M" sort="Brollo, M" uniqKey="Brollo M" first="M" last="Brollo">M. Brollo</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Suresnes</settlement></placeName></affiliation></author><author><name sortKey="Naline, E" sort="Naline, E" uniqKey="Naline E" first="E" last="Naline">E. Naline</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Montigny-Le-Bretonneux</settlement></placeName></affiliation></author><author><name sortKey="Devillier, P" sort="Devillier, P" uniqKey="Devillier P" first="P" last="Devillier">P. Devillier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacologie respiratoire UPRES EA220, hôpital Foch, 11, rue Guillaume-Lenoir, 92150 Suresnes, France; Université Versailles Saint-Quentin, UFR sciences de la santé Simone-Veil, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Montigny-Le-Bretonneux</settlement></placeName></affiliation></author></analytic><series><title level="j">Revue de pneumologie clinique</title><idno type="eISSN">1776-2561</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cilia (physiology)</term><term>Epithelial Cells (physiology)</term><term>Humans</term><term>Lung (chemistry)</term><term>Lung (cytology)</term><term>Lung (physiology)</term><term>Muscle Relaxation (physiology)</term><term>Myocytes, Smooth Muscle (physiology)</term><term>Receptors, Cell Surface (physiology)</term><term>Receptors, G-Protein-Coupled (agonists)</term><term>Receptors, G-Protein-Coupled (physiology)</term><term>Taste (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules épithéliales (physiologie)</term><term>Cils vibratiles (physiologie)</term><term>Goût (physiologie)</term><term>Humains</term><term>Myocytes du muscle lisse (physiologie)</term><term>Poumon ()</term><term>Poumon (cytologie)</term><term>Poumon (physiologie)</term><term>Relâchement musculaire (physiologie)</term><term>Récepteurs couplés aux protéines G (agonistes)</term><term>Récepteurs couplés aux protéines G (physiologie)</term><term>Récepteurs de surface cellulaire (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Cell Surface</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" qualifier="agonistes" xml:lang="fr"><term>Récepteurs couplés aux protéines G</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Cils vibratiles</term><term>Goût</term><term>Myocytes du muscle lisse</term><term>Poumon</term><term>Relâchement musculaire</term><term>Récepteurs couplés aux protéines G</term><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cilia</term><term>Epithelial Cells</term><term>Lung</term><term>Muscle Relaxation</term><term>Myocytes, Smooth Muscle</term><term>Taste</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Poumon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The receptors responsible for taste perception distinguish the four basic tastes : salty, sweet, bitter and umami. Among them, the bitter taste receptors (TAS2R) are G protein coupled receptors, including 25 subtypes identified in humans to date. Although the existence of endogenous agonists remains uncertain, the TAS2R receptors have the ability to recognize natural or synthetic molecules, as various molecules produced by bacteria, or caffeine, chloroquine, or erythromycin. The expression of these receptors, initially thought to be confined to the oral cavity, has recently been described in extra-oral tissues such as the gastrointestinal tract and the lungs. The effects in the lung tissue are essentially at three levels : TAS2R receptors expressed on the cilia of epithelial cells increase the cilia vibration frequency; the stimulation of TAS2R receptors expressed in bronchial smooth muscle cells leads to bronchial relaxation; while TAS2R receptors expressed on immune cells in the lung tissue, including macrophages, are involved in the modulation of the production of pro-inflammatory cytokines. In conclusion, in view of these complementary mechanisms, TAS2R receptors may become a pharmacological target of interest for the treatment of obstructive lung diseases. </div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Montigny-Le-Bretonneux</li><li>Suresnes</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Grassin Delyle, S" sort="Grassin Delyle, S" uniqKey="Grassin Delyle S" first="S" last="Grassin-Delyle">S. Grassin-Delyle</name></region><name sortKey="Abrial, C" sort="Abrial, C" uniqKey="Abrial C" first="C" last="Abrial">C. Abrial</name><name sortKey="Brollo, M" sort="Brollo, M" uniqKey="Brollo M" first="M" last="Brollo">M. Brollo</name><name sortKey="Devillier, P" sort="Devillier, P" uniqKey="Devillier P" first="P" last="Devillier">P. Devillier</name><name sortKey="Naline, E" sort="Naline, E" uniqKey="Naline E" first="E" last="Naline">E. Naline</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000175 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000175 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= France
|étape= Analysis
|type= RBID
|clé= pubmed:24646786
|texte= [Taste receptors in the lungs: interesting or anecdotal?].
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:24646786" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |